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Nugrahaeni, Asri Dewanti Adhi
- Topical Application of Citrus limon Peel Essential Oil Increased Pro-Inflammatory Cytokines Expression on Type IV Hypersensitivity Reaction
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Authors
Fatma Yasmin Mahdani
1,
Ulyasari Rachmaningayu
2,
Elva Anjani
2,
Asri Dewanti Adhi Nugrahaeni
2,
Naqiya Ayunnisa
3,
Salsabila Fitriana Putri
3,
Meircurius Dwi Condro Surboyo
1,
Nurina Febriyanti Ayuningtyas
1,
Priyo Hadi
1,
Hening Tuti Hendarti
1,
Diah Savitri Ernawati
1
Affiliations
1 Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - 60132, ID
2 Dental Profession Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - 60132, ID
3 Bachelor Dental Science Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - 60132, ID
1 Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - 60132, ID
2 Dental Profession Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - 60132, ID
3 Bachelor Dental Science Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - 60132, ID
Source
International Journal of Medical and Dental Sciences, Vol 12, No 1 (2023), Pagination: 2063-2070Abstract
Introduction: Citrus limon peels essential oil has the potential to be developed as a topical medicine due to its active components. The essential oil has been demonstrated in numerous studies to have anti-inflammatory, anti-microbial, antifungal, and antioxidant properties. A study is required to determine whether Citrus limon peel essential oil can cause a type IV hypersensitivity reaction by examining the expression of the cytokines TNF-, IL-1, and IL-6 as well as the clinical manifestations on an animal skin. In this study, the effect of topically applying the essential oil of Citrus limon peel on the expression of TNF-α, IL-1, and IL-6 as well as on type IV hypersensitivity reaction symptoms was examined. Methods: This study is based on the guinea-pig maximisation test method in NADFC RI Regulation Number 7 of 2014, with two groups (control group and treatment group) for each set of ten samples. Citrus limon peels essential oil was administered to the treatment group, whereas CMC-Na was given to the control group. Animal models were euthanized after which the tissues were prepared as specimens for immunohistochemical staining. The expression of cytokines was computed and examined using a light microscope. Results: There were no clinical signs of type IV hypersensitivity in either group, and the expression of TNF-α, IL-1 and IL-6 in the treatment group was found higher than in the control group. Conclusion: After topical administration of Citrus limon peels essential oil, there was an increase in the expression of TNF-α, IL-1 and IL-6 without any clinical symptoms of type IV hypersensitivity.Keywords
Citrus limon, Essential Oil, IL-6, TNF-α, IL-1, Type IV HypersensitivityFull Text
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